Scale-Up Laboratory

AbbVie is an international biopharmaceutical research and manufacturing company focused on immunology, oncology, neuroscience, virology and general medicine. Its Worcester, MA operations supports both research and manufacturing space, and have undergone a variety of renovations in recent years to maintain competitive in the R&D market.

One of those renovations, the Scale Up Laboratory, required the reconfiguration of adjacent laboratory spaces to support a larger, more unified lab housing process development operations and equipment including bioreactors, centrifuges, chromatography skids, buffer and media preparation and storage and filtration operations. To achieve this, Consigli managed the structural demolition and reconfiguration of the space; installation of condenser pads; tie-ins and redistribution of existing M/E/Ps; and the installation of new finishes, flooring and casework. Additionally, existing instrument air, carbon dioxide, oxygen, nitrogen, process vent, chilled water, RODI and clean steam process systems were redistributed, and stainless steel process waste headers were installed. All work was completed within an occupied laboratory building, including immediately adjacent to occupied offices and research labs, requiring carefully coordinated shutdowns and project coordination.